Real Madrid are going to win La Liga. It's better to come to terms with this now so you can actually enjoy the season. If you go into the season thinking someone else might have a chance and Real Madrid open up a 10-point lead by Christmas, you are going to be disappointed. So ward off the disappointment. Barcelona are depleted and Atletico Madrid are plucky but outgunned. Real Madrid are going to win La Liga.
This is fine! Lots of people enjoy the Bundesliga even though they know Bayern Munich are going to win. You can still enjoy the season even if you know how it ends already.